Pifithrin-α, p-Nitro, Cyclic

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pifithrin-α, p-Nitro, Cyclic (PFN-α) 是 p53 的细胞渗透性活性抑制剂。

Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form inhibitor of p53.

Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.

Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.Pifithrin-α, p-Nitro, Cyclic shows the half-life (t1/2) of 6 hours (when incubated in biological conditions).

PFN-α

Apoptosis

p53

P53

——

——

60477-38-5

299.35

C15H13N3O2S

>98% (HPLC)

DMSO:5 mg/mL (16.70 mM; Need ultrasonic);DMF:12.5 mg/mL (41.76 mM; Need ultrasonic)

C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]

——

(-20℃)

With Ice Pack

≥ 2 years